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Nephrogenic Diabetes Insipidus

Symptoms of Diabetes Insipidus

Diabetes Insipidus is a rare condition that occurs when the kidneys cannot conserve water as they filter toxins from the blood. As such, people with Diabetes Insipidus generally have a constant urge to urinate and frequently feel thirsty. This is not glucose-based Diabetes mellitus.

The Hypothalamus

The HypothalamusIn a normal body, a hormone called ADH (antidiuretic hormone) controls the amount of water that the kidneys release. ADH, also called vasopressin (VAS-oh-pres-in), is a hormone that is produced in thehypothalamus (HY-puh-thal-uh-muss) region of the brain. The pituitary (pee-TOO-ee-ter-ee) gland, which is located at the base of the brain, releases the ADH hormone in order to control the release of urine.

However, when a person has Diabetes Insipidus (in-sip-i-duh s), he or she does not have ADH (called central Diabetes Insipidus) or has kidneys that do not respond to ADH (called nephrogenic (NE-froj-e-nik) Diabetes Insipidus (in-SIP-i-duss)). As such, a patient will urinate frequently. The frequent loss of water causes the patient to be constantly thirsty.






Symptoms: Excessive urination and Extreme thirst

Diabetes Insipidus Causes

Central Diabetes Insipidus is almost always caused by damage to the brain in the pituitary gland or hypothalamus region, though birth defects can also cause the condition. The damage usually is the result of surgery, infection, abnormal growths, or head injuries.

Nephrogenic Diabetes Insipidus is often caused by medications that make it impossible for the kidneys to reabsorb water back into the bloodstream. The condition may also be inherited from the maternal side.

Diabetes Insipidus Complications
- Dry skin
- Dry mucous membranes
- Sunken eyes
- Fever
- Rapid heart rate
- Unexplained weight loss
- Fatigue
- Electrolyte imbalance
- Headaches
- Irritability
- Muscle pain
Diabetes Insipidus Treatment

Central Diabetes Insipidus is generally treated through medications. Vasopressin, which is administered through a nasal spray or tablets, is the most common medication used to treat Diabetes Insipidus.

Nephrogenic Diabetes Insipidus may be caused by medications. Once the medications are stopped, the condition may go away. If not, then a person with Nephrogenic Diabetes Insipidus may have to drink fluids to counteract those fluids that the body expels. Additionally, patients with Nephrogenic Diabetes Insipidus may take medications to reduce the need to urinate.

Contact your healthcare provider immediately if you think you have Diabetes Insipidus.

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Nephrogenic Diabetes Insipidus
Nephrogenic Diabetes Insipidus